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Highlights on F0

Abstract This paper summarizes the concept of F0 and its related parameters (D, z). Essential notions on sterilization kinetics are explained. The idea of physical and biological “equivalent time” is presented and its application in moist-heat sterilization processes is discussed.   Introduction It has been experimentally shown that the reaction of thermal degradation of microorganisms […]
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What is a sterilization autoclave?

ABSTRACT This short article is an introduction to the basic selection of sterilization autoclaves. It defines this type of equipment, summarizes the varieties available and discuss the preliminary problems to cope with in specification and design of sterilization autoclaves. GENERALS Both thermal and chemical actions are suitable for sterilization. Thermal sterilization of pharmaceutical products may […]
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F0 value – What it means, how to calculate it and how to use it in moist-heat sterilization

Introduction The purpose of this Fedegari Technical Note, firstly distributed in 1988 and perseveringly revised, is to clarify the nature of F0 and its related parameters (D, z, PNSU/SAL), and to explain their use and limits for the setting, adjustment, control and validation of moist-heat sterilization processes. The F0 algorithm was first introduced in 1968 […]
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